ChloroquineV1, Main, Exploration, bibRecord, 000037

Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel

Identifieur interne : 000037 ( Main/Exploration ); précédent : 000036; suivant : 000038

Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel

Source :

Theranostics [ 1838-7640 ] ; 2020.

RBID : PMC:7053188

Abstract

Simultaneously targeted treatment of tumor cells and their surrounding growth-supporting immune cells is a promising strategy to reshape immunosuppressive tumor microenvironment (TME) and potentiate host innate and adaptive antitumor immune responses.

Methods: We designed a series of melittin-(RADA)_n hybrid peptide sequences with varying self-assembling motifs of RADA and screened out a melittin-(RADA)₆ peptide that has an optimal gel-formation ability and in vitro antitumor activity.

Results: The formed melittin-(RADA)₆ (MR₅₂) hydrogel scaffold could be loaded with a specific Ca²⁺/calmodulin-dependent protein kinase II (CAMKII) inhibitor, KN93, originally found to have both direct tumoricidal activity and macrophages-reprogramming ability, for potent immunotherapy against melanoma and hepatoma ascites in mice models. Our MR₅₂ hydrogel has an interweaving nanofiber-like structure, possesses direct antitumor and controlled drug release properties, and promotes the enhanced intracellular uptake of loaded cargo. Compared to free KN93, the MR₅₂-KN93 hydrogel (MRK) improved the killing effects and levels of immunogenic cell death (ICD) on tumor cells significantly. Due to the dual role of KN93, the injection of the MRK hydrogel retarded the growth of subcutaneous melanoma tumors dramatically and resulted in a high number of mature dendritic cells of draining lymph nodes, significantly enhancing the portion of cytotoxic T cells and reduced number of M2-like tumor-associated macrophages (TAMs) in tumors. Using a mouse model of malignant ascites (MAs), where traditional therapy was ineffective, we demonstrated that the MRK hydrogel treatment offered a significantly prolonged survival compared to controls. Following treatment with the MRK hydrogel, macrophages had elevated programmed cell death protein ligand-1 (PD-L1) expression, promising follow-up combined anti-PD-1 therapy that confers a cure rate of approximately 30% against MAs in mice models.

Conclusion: Thus, the MRK hydrogel may serve as a prospective platform for antitumor applications.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053188

DOI: 10.7150/thno.42385
PubMed: 32194854
PubMed Central: 7053188

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel</title>
<author><name sortKey="Dai, Xiaomeng" sort="Dai, Xiaomeng" uniqKey="Dai X" first="Xiaomeng" last="Dai">Xiaomeng Dai</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
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</author>
<author><name sortKey="Meng, Jingshu" sort="Meng, Jingshu" uniqKey="Meng J" first="Jingshu" last="Meng">Jingshu Meng</name>
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<author><name sortKey="Deng, Suke" sort="Deng, Suke" uniqKey="Deng S" first="Suke" last="Deng">Suke Deng</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Zhang, Lingling" sort="Zhang, Lingling" uniqKey="Zhang L" first="Lingling" last="Zhang">Lingling Zhang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
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</placeName>
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<author><name sortKey="Wan, Chao" sort="Wan, Chao" uniqKey="Wan C" first="Chao" last="Wan">Chao Wan</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lu, Lisen" sort="Lu, Lisen" uniqKey="Lu L" first="Lisen" last="Lu">Lisen Lu</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Jing" sort="Huang, Jing" uniqKey="Huang J" first="Jing" last="Huang">Jing Huang</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Yan" sort="Hu, Yan" uniqKey="Hu Y" first="Yan" last="Hu">Yan Hu</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
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<author><name sortKey="Zhang, Zhanjie" sort="Zhang, Zhanjie" uniqKey="Zhang Z" first="Zhanjie" last="Zhang">Zhanjie Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
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<author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
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<author><name sortKey="Lovell, Jonathan F" sort="Lovell, Jonathan F" uniqKey="Lovell J" first="Jonathan F." last="Lovell">Jonathan F. Lovell</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Chemical and Biological Engineering, University at Buffalo, State University of New York. Buffalo, New York 14260, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemical and Biological Engineering, University at Buffalo, State University of New York. Buffalo, New York 14260</wicri:regionArea>
<orgName type="university">Université d'État de New York à Buffalo</orgName>
<placeName><settlement type="city">Buffalo (New York)</settlement>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, Gang" sort="Wu, Gang" uniqKey="Wu G" first="Gang" last="Wu">Gang Wu</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Kunyu" sort="Yang, Kunyu" uniqKey="Yang K" first="Kunyu" last="Yang">Kunyu Yang</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jin, Honglin" sort="Jin, Honglin" uniqKey="Jin H" first="Honglin" last="Jin">Honglin Jin</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Theranostics</title>
<idno type="eISSN">1838-7640</idno>
<imprint><date when="2020">2020</date>
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<front><div type="abstract" xml:lang="en"><p>Simultaneously targeted treatment of tumor cells and their surrounding growth-supporting immune cells is a promising strategy to reshape immunosuppressive tumor microenvironment (TME) and potentiate host innate and adaptive antitumor immune responses.</p>
<p><bold>Methods</bold>
: We designed a series of melittin-(RADA)<sub>n</sub>
 hybrid peptide sequences with varying self-assembling motifs of RADA and screened out a melittin-(RADA)<sub>6</sub>
 peptide that has an optimal gel-formation ability and <italic>in vitro</italic>
 antitumor activity.</p>
<p><bold>Results</bold>
: The formed melittin-(RADA)<sub>6</sub>
 (MR<sub>52</sub>
) hydrogel scaffold could be loaded with a specific Ca<sup>2+</sup>
/calmodulin-dependent protein kinase II (CAMKII) inhibitor, KN93, originally found to have both direct tumoricidal activity and macrophages-reprogramming ability, for potent immunotherapy against melanoma and hepatoma ascites in mice models. Our MR<sub>52</sub>
 hydrogel has an interweaving nanofiber-like structure, possesses direct antitumor and controlled drug release properties<italic>,</italic>
 and promotes the enhanced intracellular uptake of loaded cargo. Compared to free KN93, the MR<sub>52</sub>
-KN93 hydrogel (MRK) improved the killing effects and levels of immunogenic cell death (ICD) on tumor cells significantly. Due to the dual role of KN93, the injection of the MRK hydrogel retarded the growth of subcutaneous melanoma tumors dramatically and resulted in a high number of mature dendritic cells of draining lymph nodes, significantly enhancing the portion of cytotoxic T cells and reduced number of M2-like tumor-associated macrophages (TAMs) in tumors. Using a mouse model of malignant ascites (MAs), where traditional therapy was ineffective, we demonstrated that the MRK hydrogel treatment offered a significantly prolonged survival compared to controls. Following treatment with the MRK hydrogel, macrophages had elevated programmed cell death protein ligand-1 (PD-L1) expression, promising follow-up combined anti-PD-1 therapy that confers a cure rate of approximately 30% against MAs in mice models.</p>
<p><bold>Conclusion</bold>
: Thus, the MRK hydrogel may serve as a prospective platform for antitumor applications.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Holzel, M" uniqKey="Holzel M">M Holzel</name>
</author>
<author><name sortKey="Bovier, A" uniqKey="Bovier A">A Bovier</name>
</author>
<author><name sortKey="Tuting, T" uniqKey="Tuting T">T Tuting</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zou, W" uniqKey="Zou W">W Zou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nagarsheth, N" uniqKey="Nagarsheth N">N Nagarsheth</name>
</author>
<author><name sortKey="Wicha, Ms" uniqKey="Wicha M">MS Wicha</name>
</author>
<author><name sortKey="Zou, W" uniqKey="Zou W">W Zou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Draghiciu, O" uniqKey="Draghiciu O">O Draghiciu</name>
</author>
<author><name sortKey="Lubbers, J" uniqKey="Lubbers J">J Lubbers</name>
</author>
<author><name sortKey="Nijman, Hw" uniqKey="Nijman H">HW Nijman</name>
</author>
<author><name sortKey="Daemen, T" uniqKey="Daemen T">T Daemen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schmall, A" uniqKey="Schmall A">A Schmall</name>
</author>
<author><name sortKey="Al Tamari, Hm" uniqKey="Al Tamari H">HM Al-Tamari</name>
</author>
<author><name sortKey="Herold, S" uniqKey="Herold S">S Herold</name>
</author>
<author><name sortKey="Kampschulte, M" uniqKey="Kampschulte M">M Kampschulte</name>
</author>
<author><name sortKey="Weigert, A" uniqKey="Weigert A">A Weigert</name>
</author>
<author><name sortKey="Wietelmann, A" uniqKey="Wietelmann A">A Wietelmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mantovani, A" uniqKey="Mantovani A">A Mantovani</name>
</author>
<author><name sortKey="Marchesi, F" uniqKey="Marchesi F">F Marchesi</name>
</author>
<author><name sortKey="Malesci, A" uniqKey="Malesci A">A Malesci</name>
</author>
<author><name sortKey="Laghi, L" uniqKey="Laghi L">L Laghi</name>
</author>
<author><name sortKey="Allavena, P" uniqKey="Allavena P">P Allavena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Togashi, Y" uniqKey="Togashi Y">Y Togashi</name>
</author>
<author><name sortKey="Shitara, K" uniqKey="Shitara K">K Shitara</name>
</author>
<author><name sortKey="Nishikawa, H" uniqKey="Nishikawa H">H Nishikawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cassetta, L" uniqKey="Cassetta L">L Cassetta</name>
</author>
<author><name sortKey="Pollard, Jw" uniqKey="Pollard J">JW Pollard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pathria, P" uniqKey="Pathria P">P Pathria</name>
</author>
<author><name sortKey="Louis, Tl" uniqKey="Louis T">TL Louis</name>
</author>
<author><name sortKey="Varner, Ja" uniqKey="Varner J">JA Varner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arlauckas, Sp" uniqKey="Arlauckas S">SP Arlauckas</name>
</author>
<author><name sortKey="Garren, Sb" uniqKey="Garren S">SB Garren</name>
</author>
<author><name sortKey="Garris, Cs" uniqKey="Garris C">CS Garris</name>
</author>
<author><name sortKey="Kohler, Rh" uniqKey="Kohler R">RH Kohler</name>
</author>
<author><name sortKey="Oh, J" uniqKey="Oh J">J Oh</name>
</author>
<author><name sortKey="Pittet, Mj" uniqKey="Pittet M">MJ Pittet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martinez, Fo" uniqKey="Martinez F">FO Martinez</name>
</author>
<author><name sortKey="Sica, A" uniqKey="Sica A">A Sica</name>
</author>
<author><name sortKey="Mantovani, A" uniqKey="Mantovani A">A Mantovani</name>
</author>
<author><name sortKey="Locati, M" uniqKey="Locati M">M Locati</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murray, Pj" uniqKey="Murray P">PJ Murray</name>
</author>
<author><name sortKey="Allen, Je" uniqKey="Allen J">JE Allen</name>
</author>
<author><name sortKey="Biswas, Sk" uniqKey="Biswas S">SK Biswas</name>
</author>
<author><name sortKey="Fisher, Ea" uniqKey="Fisher E">EA Fisher</name>
</author>
<author><name sortKey="Gilroy, Dw" uniqKey="Gilroy D">DW Gilroy</name>
</author>
<author><name sortKey="Goerdt, S" uniqKey="Goerdt S">S Goerdt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rodell, Cb" uniqKey="Rodell C">CB Rodell</name>
</author>
<author><name sortKey="Ahmed, Ms" uniqKey="Ahmed M">MS Ahmed</name>
</author>
<author><name sortKey="Garris, Cs" uniqKey="Garris C">CS Garris</name>
</author>
<author><name sortKey="Pittet, Mj" uniqKey="Pittet M">MJ Pittet</name>
</author>
<author><name sortKey="Weissleder, R" uniqKey="Weissleder R">R Weissleder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reichel, D" uniqKey="Reichel D">D Reichel</name>
</author>
<author><name sortKey="Tripathi, M" uniqKey="Tripathi M">M Tripathi</name>
</author>
<author><name sortKey="Perez, Jm" uniqKey="Perez J">JM Perez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, D" uniqKey="Chen D">D Chen</name>
</author>
<author><name sortKey="Xie, J" uniqKey="Xie J">J Xie</name>
</author>
<author><name sortKey="Fiskesund, R" uniqKey="Fiskesund R">R Fiskesund</name>
</author>
<author><name sortKey="Dong, W" uniqKey="Dong W">W Dong</name>
</author>
<author><name sortKey="Liang, X" uniqKey="Liang X">X Liang</name>
</author>
<author><name sortKey="Lv, J" uniqKey="Lv J">J Lv</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gu, Y" uniqKey="Gu Y">Y Gu</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
<author><name sortKey="Ma, X" uniqKey="Ma X">X Ma</name>
</author>
<author><name sortKey="Kim, Bw" uniqKey="Kim B">BW Kim</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pellicena, P" uniqKey="Pellicena P">P Pellicena</name>
</author>
<author><name sortKey="Schulman, H" uniqKey="Schulman H">H Schulman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Yy" uniqKey="Wang Y">YY Wang</name>
</author>
<author><name sortKey="Zhao, R" uniqKey="Zhao R">R Zhao</name>
</author>
<author><name sortKey="Zhe, H" uniqKey="Zhe H">H Zhe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doran, Ac" uniqKey="Doran A">AC Doran</name>
</author>
<author><name sortKey="Ozcan, L" uniqKey="Ozcan L">L Ozcan</name>
</author>
<author><name sortKey="Cai, B" uniqKey="Cai B">B Cai</name>
</author>
<author><name sortKey="Zheng, Z" uniqKey="Zheng Z">Z Zheng</name>
</author>
<author><name sortKey="Fredman, G" uniqKey="Fredman G">G Fredman</name>
</author>
<author><name sortKey="Rymond, Cc" uniqKey="Rymond C">CC Rymond</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naahidi, S" uniqKey="Naahidi S">S Naahidi</name>
</author>
<author><name sortKey="Jafari, M" uniqKey="Jafari M">M Jafari</name>
</author>
<author><name sortKey="Logan, M" uniqKey="Logan M">M Logan</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name>
</author>
<author><name sortKey="Bae, H" uniqKey="Bae H">H Bae</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meng, Z" uniqKey="Meng Z">Z Meng</name>
</author>
<author><name sortKey="Zhou, X" uniqKey="Zhou X">X Zhou</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name>
</author>
<author><name sortKey="Han, X" uniqKey="Han X">X Han</name>
</author>
<author><name sortKey="Dong, Z" uniqKey="Dong Z">Z Dong</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chao, Y" uniqKey="Chao Y">Y Chao</name>
</author>
<author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name>
</author>
<author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gelain, F" uniqKey="Gelain F">F Gelain</name>
</author>
<author><name sortKey="Unsworth, Ld" uniqKey="Unsworth L">LD Unsworth</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Yu, S" uniqKey="Yu S">S Yu</name>
</author>
<author><name sortKey="Wen, D" uniqKey="Wen D">D Wen</name>
</author>
<author><name sortKey="Hu, Q" uniqKey="Hu Q">Q Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, S" uniqKey="Yu S">S Yu</name>
</author>
<author><name sortKey="He, C" uniqKey="He C">C He</name>
</author>
<author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name>
</author>
<author><name sortKey="Zhan, J" uniqKey="Zhan J">J Zhan</name>
</author>
<author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bechinger, B" uniqKey="Bechinger B">B Bechinger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jin, H" uniqKey="Jin H">H Jin</name>
</author>
<author><name sortKey="Wan, C" uniqKey="Wan C">C Wan</name>
</author>
<author><name sortKey="Zou, Z" uniqKey="Zou Z">Z Zou</name>
</author>
<author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Geng, Y" uniqKey="Geng Y">Y Geng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krysko, Dv" uniqKey="Krysko D">DV Krysko</name>
</author>
<author><name sortKey="Garg, Ad" uniqKey="Garg A">AD Garg</name>
</author>
<author><name sortKey="Kaczmarek, A" uniqKey="Kaczmarek A">A Kaczmarek</name>
</author>
<author><name sortKey="Krysko, O" uniqKey="Krysko O">O Krysko</name>
</author>
<author><name sortKey="Agostinis, P" uniqKey="Agostinis P">P Agostinis</name>
</author>
<author><name sortKey="Vandenabeele, P" uniqKey="Vandenabeele P">P Vandenabeele</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menger, L" uniqKey="Menger L">L Menger</name>
</author>
<author><name sortKey="Vacchelli, E" uniqKey="Vacchelli E">E Vacchelli</name>
</author>
<author><name sortKey="Adjemian, S" uniqKey="Adjemian S">S Adjemian</name>
</author>
<author><name sortKey="Martins, I" uniqKey="Martins I">I Martins</name>
</author>
<author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name>
</author>
<author><name sortKey="Shen, S" uniqKey="Shen S">S Shen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kubo, H" uniqKey="Kubo H">H Kubo</name>
</author>
<author><name sortKey="Loegering, Da" uniqKey="Loegering D">DA Loegering</name>
</author>
<author><name sortKey="Tohda, Y" uniqKey="Tohda Y">Y Tohda</name>
</author>
<author><name sortKey="Bankers Fulbright, J" uniqKey="Bankers Fulbright J">J Bankers-Fulbright</name>
</author>
<author><name sortKey="Weiler, Cr" uniqKey="Weiler C">CR Weiler</name>
</author>
<author><name sortKey="Nakajima, H" uniqKey="Nakajima H">H Nakajima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name>
</author>
<author><name sortKey="Li, R" uniqKey="Li R">R Li</name>
</author>
<author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name>
</author>
<author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y Zheng</name>
</author>
<author><name sortKey="Qian, J" uniqKey="Qian J">J Qian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gardner, A" uniqKey="Gardner A">A Gardner</name>
</author>
<author><name sortKey="Ruffell, B" uniqKey="Ruffell B">B Ruffell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Ds" uniqKey="Chen D">DS Chen</name>
</author>
<author><name sortKey="Mellman, I" uniqKey="Mellman I">I Mellman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Joyce, Ja" uniqKey="Joyce J">JA Joyce</name>
</author>
<author><name sortKey="Fearon, Dt" uniqKey="Fearon D">DT Fearon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andrews, Mc" uniqKey="Andrews M">MC Andrews</name>
</author>
<author><name sortKey="Wargo, Ja" uniqKey="Wargo J">JA Wargo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eroglu, Z" uniqKey="Eroglu Z">Z Eroglu</name>
</author>
<author><name sortKey="Zaretsky, Jm" uniqKey="Zaretsky J">JM Zaretsky</name>
</author>
<author><name sortKey="Hu Lieskovan, S" uniqKey="Hu Lieskovan S">S Hu-Lieskovan</name>
</author>
<author><name sortKey="Kim, Dw" uniqKey="Kim D">DW Kim</name>
</author>
<author><name sortKey="Algazi, A" uniqKey="Algazi A">A Algazi</name>
</author>
<author><name sortKey="Johnson, Db" uniqKey="Johnson D">DB Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lambert, La" uniqKey="Lambert L">LA Lambert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kipps, E" uniqKey="Kipps E">E Kipps</name>
</author>
<author><name sortKey="Tan, Ds" uniqKey="Tan D">DS Tan</name>
</author>
<author><name sortKey="Kaye, Sb" uniqKey="Kaye S">SB Kaye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, Cg" uniqKey="Park C">CG Park</name>
</author>
<author><name sortKey="Hartl, Ca" uniqKey="Hartl C">CA Hartl</name>
</author>
<author><name sortKey="Schmid, D" uniqKey="Schmid D">D Schmid</name>
</author>
<author><name sortKey="Carmona, Em" uniqKey="Carmona E">EM Carmona</name>
</author>
<author><name sortKey="Kim, Hj" uniqKey="Kim H">HJ Kim</name>
</author>
<author><name sortKey="Goldberg, Ms" uniqKey="Goldberg M">MS Goldberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bauleth Ramos, T" uniqKey="Bauleth Ramos T">T Bauleth-Ramos</name>
</author>
<author><name sortKey="Shih, Ty" uniqKey="Shih T">TY Shih</name>
</author>
<author><name sortKey="Shahbazi, Ma" uniqKey="Shahbazi M">MA Shahbazi</name>
</author>
<author><name sortKey="Najibi, Aj" uniqKey="Najibi A">AJ Najibi</name>
</author>
<author><name sortKey="Mao, As" uniqKey="Mao A">AS Mao</name>
</author>
<author><name sortKey="Liu, Df" uniqKey="Liu D">DF Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xue, K" uniqKey="Xue K">K Xue</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Yong, P" uniqKey="Yong P">P Yong</name>
</author>
<author><name sortKey="Young, D" uniqKey="Young D">D Young</name>
</author>
<author><name sortKey="Wu, Y L" uniqKey="Wu Y">Y-L Wu</name>
</author>
<author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naskar, J" uniqKey="Naskar J">J Naskar</name>
</author>
<author><name sortKey="Palui, G" uniqKey="Palui G">G Palui</name>
</author>
<author><name sortKey="Banerjee, A" uniqKey="Banerjee A">A Banerjee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Basak, S" uniqKey="Basak S">S Basak</name>
</author>
<author><name sortKey="Nandi, N" uniqKey="Nandi N">N Nandi</name>
</author>
<author><name sortKey="Bhattacharyya, K" uniqKey="Bhattacharyya K">K Bhattacharyya</name>
</author>
<author><name sortKey="Datta, A" uniqKey="Datta A">A Datta</name>
</author>
<author><name sortKey="Banerjee, A" uniqKey="Banerjee A">A Banerjee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jin, H" uniqKey="Jin H">H Jin</name>
</author>
<author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name>
</author>
<author><name sortKey="Hu, J" uniqKey="Hu J">J Hu</name>
</author>
<author><name sortKey="Ren, Q" uniqKey="Ren Q">Q Ren</name>
</author>
<author><name sortKey="Yang, K" uniqKey="Yang K">K Yang</name>
</author>
<author><name sortKey="Wan, C" uniqKey="Wan C">C Wan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moughon, Dl" uniqKey="Moughon D">DL Moughon</name>
</author>
<author><name sortKey="He, H" uniqKey="He H">H He</name>
</author>
<author><name sortKey="Schokrpur, S" uniqKey="Schokrpur S">S Schokrpur</name>
</author>
<author><name sortKey="Jiang, Zk" uniqKey="Jiang Z">ZK Jiang</name>
</author>
<author><name sortKey="Yaqoob, M" uniqKey="Yaqoob M">M Yaqoob</name>
</author>
<author><name sortKey="David, J" uniqKey="David J">J David</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Han, X" uniqKey="Han X">X Han</name>
</author>
<author><name sortKey="An, L" uniqKey="An L">L An</name>
</author>
<author><name sortKey="Yan, D" uniqKey="Yan D">D Yan</name>
</author>
<author><name sortKey="Hiroshi, M" uniqKey="Hiroshi M">M Hiroshi</name>
</author>
<author><name sortKey="Ding, W" uniqKey="Ding W">W Ding</name>
</author>
<author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name>
</author>
</analytic>
</biblStruct>
</listBibl>
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<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Hubei</li>
<li>État de New York</li>
</region>
<settlement><li>Buffalo (New York)</li>
<li>Wuhan</li>
</settlement>
<orgName><li>Université d'État de New York à Buffalo</li>
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<tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Dai, Xiaomeng" sort="Dai, Xiaomeng" uniqKey="Dai X" first="Xiaomeng" last="Dai">Xiaomeng Dai</name>
</region>
<name sortKey="Deng, Suke" sort="Deng, Suke" uniqKey="Deng S" first="Suke" last="Deng">Suke Deng</name>
<name sortKey="Hu, Yan" sort="Hu, Yan" uniqKey="Hu Y" first="Yan" last="Hu">Yan Hu</name>
<name sortKey="Huang, Jing" sort="Huang, Jing" uniqKey="Huang J" first="Jing" last="Huang">Jing Huang</name>
<name sortKey="Jin, Honglin" sort="Jin, Honglin" uniqKey="Jin H" first="Honglin" last="Jin">Honglin Jin</name>
<name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
<name sortKey="Lu, Lisen" sort="Lu, Lisen" uniqKey="Lu L" first="Lisen" last="Lu">Lisen Lu</name>
<name sortKey="Meng, Jingshu" sort="Meng, Jingshu" uniqKey="Meng J" first="Jingshu" last="Meng">Jingshu Meng</name>
<name sortKey="Wan, Chao" sort="Wan, Chao" uniqKey="Wan C" first="Chao" last="Wan">Chao Wan</name>
<name sortKey="Wu, Gang" sort="Wu, Gang" uniqKey="Wu G" first="Gang" last="Wu">Gang Wu</name>
<name sortKey="Yang, Kunyu" sort="Yang, Kunyu" uniqKey="Yang K" first="Kunyu" last="Yang">Kunyu Yang</name>
<name sortKey="Zhang, Lingling" sort="Zhang, Lingling" uniqKey="Zhang L" first="Lingling" last="Zhang">Lingling Zhang</name>
<name sortKey="Zhang, Zhanjie" sort="Zhang, Zhanjie" uniqKey="Zhang Z" first="Zhanjie" last="Zhang">Zhanjie Zhang</name>
</country>
<country name="États-Unis"><region name="État de New York"><name sortKey="Lovell, Jonathan F" sort="Lovell, Jonathan F" uniqKey="Lovell J" first="Jonathan F." last="Lovell">Jonathan F. Lovell</name>
</region>
</country>
</tree>
</affiliations>
</record>

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HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000037 | SxmlIndent | more

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{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:7053188
   |texte=   Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel
}}

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Serveur d'exploration Chloroquine

Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel

Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel

Source :

Abstract

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Pour générer des pages wiki

	Serveur d'exploration Chloroquine
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